Tackle Oxinflammation to uphold skin health with Silybidiol™

Givaudan Active Beauty unveils Silybidiol™, the first globally compliant alternative to the iconic CBD (cannabidiol) molecule.

Silybidiol™ is a breakthrough extract from the fruit of the milk thistle with ‘green fractionation’ designed to fight the harmful effects of urban photo-pollution and promote skin health. This alternative to the CBD molecule offers a new, holistic approach to ageing, leveraging the emerging concept of OxInflammation, the destructive cycle linking oxidative stress and inflammation.

Recently, the perception of skincare and ageing has shifted towards pre-ageing, a more positive and resilient approach emphasising the importance of self-care, focusing on prevention and overall wellbeing. It recognises the link between positive emotional wellbeing and skin condition, promoting skin health and longevity. The exposome – the set of extrinsic aggressors to which our skin is exposed – is an important factor challenging skin health and longevity. It comprises UV radiation and pollution, which disrupt the skin’s delicate OxInflammation balance – the interconnection of two key biological pathways. These factors can have a damaging cumulative effect on both skin health and emotional balance.

Silybidiol extract from milk thistle fruit
Silybidiol™ extract from milk thistle fruit, obtained through green fractionation. For restoring Oxinflammation balance.
Silybidiol™ mechanism of action and clinical efficacy

Silybidiol™ binds to cannabinoid receptors in the skin and activates cellular crosstalk leading to the activation of skin defenses and detoxification pathways to effectively maintain OxInflammation balance and promote wellbeing. Clinically tests against placebo and CBD on volunteers exposed to photo-pollution, Silybidiol™ demonstrate:

  • a drastic improvement in skin homogeneity (2.7x better than CBD),
  • enhanced skin radiance (1.6x better than CBD),
  • an improvement in wellbeing (equivalent to CBD).

Romain Reynaud, Research & Development Director, explains: “We discovered that Silybidiol™ specifically activates CB2 cannabinoid receptors and delivers the same benefits as the hero CBD molecule. As such, not only does it reduce inflammation, which improves skin tone, but it also stimulates the production of beta-endorphins, feel-good peptides that contribute to overall wellness. This dual-action mechanism underlines Silybidiol™’s efficacy in promoting healthy, radiant skin while supporting emotional wellbeing.”

Contact us to learn more about Silybidiol™.

Contact us

Please call or email us for more info.

+45 45 82 82 22


Sign up for news and updates.

I have read and agree to Alsiano's privacy policy. I can unsubscribe at any time.