28 October 2015
MICROCEL Microcrystalline Cellulose
MICROCEL from Blanver is the preferred excipient for use in tablets, capsules, granules, pellets and spheres
Microcrystalline Cellulose (MCC) is a partially depolymerised pure cellulose. Its appearance is a white, insoluble, odorless and tasteless powder, composed of highly compressible porous particles. Blanver’s MICROCEL® line consists of various types distinguished by their particle size and are typically used in tablets, capsules and pellets.
As a compression or compaction aid, MICROCEL® promotes:
• High hardness of tablets with low pressure in the tablet press
• Low friability and minimal weight variation
• Excellent die filling
• Fast disintegration
• Enhanced tablets with poor compressible APIs
MICROCEL® is the preferred excipient for use in tablets, capsules, granules, pellets and spheres, as it enhances the adsorption and absorption of drugs for solid dosage formulations. It is able to function in the applications shown in the table below.
MICROCEL types for each manufactured process
The MICROCEL range consists of four different types. The range of recommended levels of use for all applications for the four types, either in wet granulation or in direct compression, is usually between 10 and 90%. Each type is able to function in the following manufacturing processes:
• MICROCEL 101: Wet Granulation, API Adsorption/Absorption, Vegetable Extract Adsorption/Absorption and Pellet & Spheronisation;
• MICROCEL 102: Wet Granulation, Direct Compression, API Adsorption/Absorption, Vegetable Extract Adsorption/Absorption, Capsule (Automatic Filling);
• MICROCEL 12 & 200: Direct Compression, Poor Flowing APIs, API Adsorption/Absorption, Vegetable Extract Adsorption/Absorption, Capsule (Semi-Automatic Filling).
DMF (US FDA): 9201
BLANVER is a global leader with more than 30 years of experience in the production of excipients for the pharmaceutical, food and cosmetic industries. Their products comply with the highest quality standard and are present in various formulations in more than 100 countries worldwide.