09 October 2017
Tocotrienol is a more potent form of vitamin E compared to Tocopherol. DavosLife E3 has the highest concentration of mixed tocotrienols and α-tocopherol available in the market
By Dr Sharon Ling & Dr Koh Yew Ming
The increasing demand for cosmetic products raises awareness of the need for natural, safe and effective ingredients with multi-functional potential. Similarly, the obsession with a youthful appearance has become commonplace, and aging and sun-damaged skin is fast becoming a dermatologic concern.
For decades, vitamin E has been well-known for its multi-usage benefit. It is an antioxidant with healing and reparative properties that help to delay skin aging and protect cellular membranes against free radical-induced damage. Numerous studies have, however, found that Tocotrienol, a more potent form of vitamin E occurring in certain plant fruits/seeds such as palm fruits (Elaeis guineensis), exhibits superior antioxidant activity compared to the common form of vitamin E, Tocopherol. Tocotrienol’s distinct chemical structure provides the unique biochemical properties responsible for providing skin health benefits beyond antioxidation. This distinct chemical structure enables its cellular uptake in biological systems 70 times higher than α-Tocopherol (1). Tocotrienol has excellent antioxidation activity in cells up to 60 times higher than Tocopherol (3) providing the ability to help protect the skin from aging and UV-induced damage caused by constant and prolonged sun exposure.
Tocotrienols possess potent photoprotective effects
Tocotrienols have been shown to provide photoprotective effects to UV irradiation and the skin reactions (redness, swelling and itchiness) are significantly reduced. Formulations with DavosLife E3 exhibited a radical skin factor (RSF) of 4.15. The RSF measures a substance’s ability to reduce free radicals generated in the skin during UV exposure. An RSF of 4.15 suggests that Tocotrienols formulations reduce free radical production in the skin resulting from exposure to the sun’s harmful UVA and UVB rays by 76%2. Our research showed that topical application of DavosLife E3 after UV exposure can reduce the severity of redness to a level comparable to an over-the-counter anti-inflammatory gel (2).
Tocotrienols enhance wound healing
Fibroblasts are critical in supporting normal wound healing. They are involved in breaking down the fibrin clot and replacing it with extra cellular matrix (ECM) components such as collagen to support the other cells associated with effective wound healing. Tocotrienols trigger the migration of fibroblasts to the wound area suggesting Tocotrienol’s potential role in skin repair and wound healing. The skin repair properties of DavosLife E3 have been investigated using MatTek’s EpiDerm FT in-vitro skin model. The in-vitro skin was treated topically with 1% α-Tocopherol, DavosLife E3 or control. Our research indicated that after 6 days of treatment, DavosLife E3 stimulates epidermal migration and skin repair more than twice as fast as α-Tocopherol (2).
Tocotrienols maintain cellular health
Results from pre-clinical studies have shown that Tocotrienols have the ability to prevent cellular aging by reversing the effects of oxidative stress in human diploid fibroblasts (HDF). In addition, Tocotrienols increased the length of DNA structures called telomeres. Telomeres progressively grow shorter each time a cell divides. In most cells, telomere length is closely associated with cellular aging: the shorter the telomere, the older the cell (4). A randomised, double-blind, placebo-controlled study with 64 human subjects aged 37-78 years old has shown a significant reduction of DNA damage in their blood samples after 3 months of 160 mg daily dose of Tocotrienols. The positive effects continued to the end of the trial at 6 months (5). Results from these studies show that Tocotrienols have the potential for maintaining cellular health.
"Tocotrienols are clinically proven to reduce DNA damage"
Tocotrienols inhibit skin pigmentation
A study has found that Tocotrienols are effective in inhibiting the production of skin pigment, melanin, indicating a potential means for skin lightening. Our research showed Tocotrienols’ ability to promote skin lightening through inhibition of tyrosinase, the key enzyme protein in melanin biosynthesis. In the study, Tocotrienols reduce melanin production by 55% through tyrosinase inhibition that is up to 150 times more potent compared to other skin lightening agents (6).
Get to know DavosLife E3, a gift from Mother Nature
DavosLife E3 (formerly known as Naturale3) DVL range of products contain a complete spectrum of all Tocotrienol isomers (α-, β-, γ- and δ-) and α-Tocopherol, occurring naturally in an optimal ratio for overall health benefits, not limited to promoting skin health and protection. It is an amber coloured liquid miscible with oil, partially miscible with ethanol and immiscible with water. DavosLife E3 DVL is highly stable under a wide range of pH conditions and temperature range, which make it ideal for formulation of cosmetic and personal care products. With our proprietary technology, DavosLife E3 DVL 95 has the highest concentration of mixed Tocotrienols and α-Tocopherol available in the market. It is suitable for skin care applications due to its less intense colour (light yellow) and viscosity.
Be assured by DavosLife E3
Safety assessment conducted by the Cosmetic Ingredient Review (CIR) Expert Panel concluded that Tocotrienols are safe for use in cosmetics. DavosLife E3 DVL range of Tocotrienols products has been granted attestation by ECOCERT Greenlife and assessed complying with the COSMOS standard.
1. Saito, Y., Yoshida, Y., Nishio, K., Hayakawa, M. & Niki, E. Characterization of cellular uptake and distribution of vitamin E. Ann. N. Y. Acad. Sci.,2004; 1031, 368–75.
2. Davos Life: Data on File.
3. Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med., 1991, 10(5), 263-75.
4. Makpol S, Abidin AZ, Sairin K, Mazlan M, Top GM, Ngah WZ. Gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxid Med Cell Longev, 2010, 3(1), 35-43.
5. Chin SF, Hamid NA, Latiff AA, Zakaria Z, Mazlan M, Yusof YA, Karim AA, Ibahim J, Hamid Z, Ngah WZ. Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation. Nutrition, 2008, 24(1), 1–10.
6. Yap WN, Zaiden N, Xu CH, Chen A, Ong S, Teo V, Yap YL. Gamma- and delta-tocotrienols inhibit skin melanin synthesis by suppressing constitutive and UV-induced tyrosinase activation. Pigment Cell Melanoma Res., 2010, 23(5), 688-92.